![]() ![]() ![]() This sensitivity makes rapamycin a drug with very interesting properties for clinical and basic research. The name of the TOR kinase and the entire pathway describes a characteristic property – the specific and effective inhibition by rapamycin, a macrocyclic lactone of bacterial origin. In plants, these molecules have been shown to be important for pathogen defense, polar cell growth, and the remodeling of the cell wall. 2 ROS can have cytotoxic effects but also possess a very important function as signaling molecules in diverse cellular processes. 1 Mitochondrial oxidative function, which impacts aging processes, and the production of reactive oxygen species (ROS) are also strongly influenced by TOR signaling. TOR is part of two distinct multi protein complexes, namely TORC1 and TORC2, which are controlling diverse cellular processes such as autophagy, protein translation, ribosome biogenesis, and actin dynamics. The TOR kinase acts as a central component of TOR signaling and modifies several downstream proteins by phosphorylation. ![]()
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